Cardiovascular diseases are the world’s leading cause of death, with atrial fibrillation (AF) a major contributor. AF often stems from atrial cardiomyopathy—progressive structural and electrical remodeling of the heart’s atria. Current diagnostic tools provide only static or invasive insights, limiting our ability to monitor disease evolution or tailor therapies.
This doctoral project aims to transform static “digital snapshots” of the heart into longitudinal digital twins—personalized, dynamic models that evolve with the patient. By combining data assimilation, uncertainty quantification, and computational cardiac modeling and simulation, the project will integrate invasive electro-anatomic maps with non-invasive surface ECGs to reconstruct and continuously update patient-specific atrial properties.
Within a Bayesian framework, advanced filtering methods (e.g., ensemble Kalman filters) will be developed to fuse noisy, sparse clinical data with physics-based cardiac models. This approach will enable accurate estimation of hidden physiological parameters and capture disease progression over time.
The doctoral candidate will work at the intersection of mathematical modeling, scientific computing, and cardiovascular science, jointly supervised by the Krumscheid group (uncertainty quantification and data assimilation) and the Loewe group (computational cardiology and simulation). The project offers an exciting opportunity to contribute to next-generation personalized medicine and digital health.
Requirements for applicants
Project-specific requirements:
As a candidate, you should have:
- A solid background in applied mathematics (or a closely related field)
- Knowledge of Bayesian inference, stochastic simulation, and their theoretical foundations
- Basic programming skills in a general-purpose language
- An interest in working in an interdisciplinary environment
- Experience with computational cardiology is an advantage but not required
General requirements:
We are looking for excellent graduates holding master degrees, received by the start of their doctoral studies at the latest, in mathematics or the SEE disciplines (natural sciences, engineering, economics), who have sufficient proficiency in mathematics and are interested in joint research that revolves around computational methods such as mathematical models, simulation methods and data science techniques.
As an international research school, we require our doctoral researchers to have good writing and oral communication skills in English (German is optional).
Project 01 is a scholarship funded by the German Academic Exchange Service (DAAD) in the DAAD Graduate School Scholarship Program.
The following DAAD requirements for applicants apply:
- Completed Master’s degree (or equivalent) at the starting date of the scholarship / preparatory German course
- Graduation no more than six years prior to nomination (exceptions apply, see DAAD website)
- No residency in Germany for more than the past 15 months before nomination ("mobility rule")
- No completed PhD degree
- Proficiency in English (German is optional)
Funding
Funding for this scholarship is provided by the German Academic Exchange Service (DAAD).
- Duration of the funding: Up to 4 years
- Monthly payments of € 1,400 (note: this will be supplemented by KIT with a part-time job with an additional income of € 556 gross per month)
- a travel allowance
- payments towards health, accident and personal liability insurance cover
- a research allowance of up to € 460
- a preparatory German language course (if available, applicable and feasible, taking into account the starting date of the scholarship)
- a material resources and supervision allowance of currently € 1,000 per year, which is paid upon application to the host institution.
Under certain circumstances, grant holders may receive the following additional benefits:
- monthly rent subsidy (calculated individually, usually about € 50 to 125 per month);
- monthly allowance for accompanying family members (about € 200 child allowance per child and about € 275 marriage allowance);
- in the case of a disability or chronic illness: subsidy for additional costs which result from the disability or chronic illness and are not covered by other funding providers